Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice
نویسندگان
چکیده
منابع مشابه
Malignant Hypertension Associated with Rhabdomyosarcoma
The Hypertension is divided into two types: primary and secondary. the secondary type, is particularly due to renal and arterial origin and is mostly seen. In children the Secondary hypertension caused by malignancies is rare. This is a case of abdominal rhabdomyosarcoma with malignant hypertension.
متن کاملLeptin and the Regulation of Renal Sodium Handling and Renal Na+-Transporting ATPases: Role in the Pathogenesis of Arterial Hypertension
Leptin, an adipose tissue hormone which regulates food intake, is also involved in the pathogenesis of arterial hypertension. Plasma leptin concentration is increased in obese individuals. Chronic leptin administration or transgenic overexpression increases blood pressure in experimental animals, and some studies indicate that plasma leptin is elevated in hypertensive subjects independently of ...
متن کاملCombination of renin-angiotensin system polymorphisms is associated with altered renal sodium handling and hypertension.
Genes of the renin-angiotensin-aldosterone system (RAAS) are natural candidates for sodium homeostasis and blood pressure regulation. To investigate the effect of a combination of polymorphisms of RAAS genes on renal sodium handling and blood pressure, 918 participants to the Olivetti Heart Study were genotyped for the following polymorphisms: I/D of angiotensin converting enzyme (ACE), M235T o...
متن کاملRenal dopaminergic defect in C57Bl/6J mice.
The C57Bl/6J mouse strain, the genetic background of many transgenic and gene knockout models, is salt sensitive and resistant to renal injury. We tested the hypothesis that renal dopaminergic function is defective in C57Bl/6J mice. On normal NaCl (0.8%, 1 wk) diet, anesthetized and conscious (telemetry) blood pressures were similar in C57Bl/6J and SJL/J mice. High NaCl (6%, 1 wk) increased blo...
متن کاملAging-associated renal disease in mice is fructokinase dependent.
Aging-associated kidney disease is usually considered a degenerative process associated with aging. Recently, it has been shown that animals can produce fructose endogenously, and that this can be a mechanism for causing kidney damage in diabetic nephropathy and in association with recurrent dehydration. We therefore hypothesized that low-level metabolism of endogenous fructose might play a rol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2018
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00546.2017